In The News updated  2/2020

 Latest 2020 ResearchDiabeloop, a French start up, recognizes that there is a subset of patients with Type 1 Diabetes that experience frequent, extreme, and unpredictable swings in blood sugar levels.  They developed an algorithm for automated insulin delivery that is currently being tested in a clinical trial on 7 patients in France ( Identifier: NCT04042207). The aim of this feasibility study is to test the safety and efficacy of the system.  More information on the trial can be found here.  More information on Diabeloop can be found here.

September 2018 an international consortium of scientists note a 36% glycemic variation as being a marker to distinguish between stable and unstable (brittle) diabetes. 

January 2017 Wanek Family donates 50,000,000 dollars to City of Hope Research Center for the cure of type 1 diabetes within the next six years


A 2016 research paper compared 42 brittle patients to 42 stable T1D’s and found “no differences in terms of global severity of psychopathological distress and specific symptoms of axis I DSM-IV-TR psychiatric diagnosis between these two groups. Axis I represent acute symptoms that need treatment such as depression, anxiety, schizophrenia and panic attacks. Some variations in personality traits appear to exist between the two groups.


      New Diagnostic Criteria is being proposed to help physicians distinguish Brittle Type 1 Diabetes ( BT1D) patients from those considered to be stable T1D’s. This criteria by doctor’s Lablanche and Benhamou from Grenoble France has been copied and pasted with their permission from a NIH clinical trial which is still recruiting participants.

     “A patient will be considered as experiencing a brittle type 1 diabetes if at least two criteria are present among: persistence of severe hypoglycemia, occurrence of ketoacidosis events without obvious etiology, diagnosis of unaware hypoglycemic episodes < 3 mmol/l based on CGM or self-monitoring blood glucose data, a mean blood glucose standard deviation>50%, MAGE index (Mean amplitude of glucose excursions)>60 mg/dl, LBGI index (low blood glucose index)>5, Clarke score≥4 or HYPOSCORE>800.”